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血清高迁移率族蛋白B1和可溶性晚期糖基化终产物受体与心力衰竭严重程度相关性研究

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摘要:

目的 探讨心力衰竭(HF)时血清高迁移率族蛋白B1(HMGB1)和可溶性晚期糖基化终 产物受体(sRAGE)的变化及二者与心脏功能和N末端脑钠肽前体(NT-proBNP)的关联。方法 选取 2014年8月至2015年1月期间就诊于哈尔滨医科大学附属第一医院心血管内科73例左室射血分数(LVEF) 小于45%的HF患者为实验组,体检人群中选择年龄、性别匹配的22例作为对照组。根据纽约心功能分 级(NYHA)将HF患者分组:Ⅱ级患者为A组(18例),Ⅲ级患者为B组(22例),Ⅳ级患者为C组(33 例)。测定各组血清HMGB1及sRAGE浓度。HF患者行心脏彩超检查并测定NT-proBNP浓度。结果 与 对照组相比,HF患者各组的血清HMGB1和sRAGE浓度显著升高(P<0.05)。且随着心功能恶化血清 HMGB1和sRAGE浓度均显著升高(P<0.05)。相关性分析结果显示,血清HMGB1和sRAGE与LVEF均 呈负相关(HMGB1 r=-0.4783,P<0.05;sRAGE r=-0.4071,P<0.05),与NT-proBNP浓度均呈正相关 (HMGB1 r=0.4850,P<0.05;sRAGE r=0.4947,P<0.05)。结论 HF患者血清HMGB1和sRAGE浓度显 著升高,二者与心功能的严重程度及NT-proBNP水平呈正相关。

Abstract:

Objective To investigate the changes of serum high mobility group protein B1 (HMGB1) and soluble advanced glycation end product receptor (sRAGE) in heart failure and their relationship with cardiac function and N-terminal brain natriuretic peptide precursor (NT-proBNP). Methods Seventy-three heart failure patients with a left ventricular ejection fraction (LVEF) of less than 45% who were treated in the Department of Cardiology of the First Affiliated Hospital of Harbin Medical University from August 2014 to January 2015 were selected as the experimental group. The age, Gender-matched 22 cases served as the control group. Patients with heart failure were grouped according to the New York Heart Function Classification (NYHA): Grade II patients were in Group A (18 patients), Grade III patients were in Group B (22 patients), and Grade IV patients were in Group C (33 patients). Serum HMGB1 and sRAGE concentrations were measured in each group. Heart failure patients underwent color Doppler ultrasound examination and determined NT-proBNP concentration. Results Compared with the control group, the serum HMGB1 and sRAGE concentrations in each group of patients with heart failure were significantly increased (P<0.05). And with the deterioration of cardiac function, serum HMGB1 and sRAGE concentrations increased significantly (P<0.05). Correlation analysis showed that serum HMGB1 and sRAGE were negatively correlated with LVEF (HMGB1 r=-0.4783, P<0.05; sRAGE r=-0.4071, P<0.05), and were positively correlated with NT-proBNP concentration (HMGB1 r=0.4850, P<0.05; sRAGE r=0.4947, P<0.05). Conclusion The levels of serum HMGB1 and sRAGE in patients with heart failure were significantly increased, and they were positively correlated with the severity of cardiac function and the level of NT-proBNP.

基金项目:

黑龙江省教育厅资助项目(12541291)

参考文献:

  • 2008

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