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慢性心力衰竭患者脂蛋白相关磷脂酶A2与超敏肌钙蛋白T、心功能的相关性

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摘要:

目的 阐明慢性心力衰竭患者血浆脂蛋白相关磷脂酶A2水平与超敏肌钙蛋白T、心力衰竭 严重程度的相关性。方法 收集2016年1月至2018年10月于粤北人民医院心血管内科初次收治的病因为心 脏瓣膜病、缺血性心肌病、扩张型心肌病的慢性心力衰竭患者,年龄50~75岁。最终共收集到慢性心力 衰竭NYHA Ⅳ级患者88例,NYHA Ⅲ级患者82例,NYHA Ⅱ级患者48例,对照组92例。检测各组患者血 浆脂蛋白相关磷脂酶A2、超敏肌钙蛋白T、氨基末端脑钠肽前体水平及左室射血分数。结果 与对照组相 比,慢性心力衰竭组患者血浆脂蛋白相关磷脂酶A2、超敏肌钙蛋白T水平均明显升高,且心功能Ⅳ组高 于心功能Ⅲ级组,心功能Ⅲ级组高于心功能Ⅱ级组,差异具有统计学意义(P<0.05)。血浆脂蛋白相关 磷脂酶A2水平与超敏肌钙蛋白T水平呈正相关(r=0.589;P<0.001)、与氨基末端脑钠肽前体水平呈正 相关(r=0.693;P<0.001)、与左室射血分数呈负相关(r=-0.535;P<0.001)。结论 血浆脂蛋白相关 磷脂酶A2水平与超敏肌钙蛋白T水平和心力衰竭严重程度呈正相关。血浆脂蛋白相关磷脂酶A2可作为慢 性心力衰竭患者新的炎症标志物,为心力衰竭的严重程度判断及发病机制提供新的依据。

Abstract:

Objective To explain the correlation among the level of plasma lipoprotein associated phospholipase A2 (Lp-PLA2), hypersensitive troponin T (hs-TnT) and severity of heart failure in patients with chronic heart failure (CHF). Methods CHF patients (aged from 50 to 75) hospitalized due to valvular disease, ischemic cardiomyopathy and dilated cardiomyopathy (DCM) were chosen from Jan. 2016 to Oct. 2018. There were finally 88 patients with CHF-NYHA Ⅳ (NYHA Ⅳ group), 82 with CHF-NYHA Ⅲ (NYHA Ⅲ group), 48 with CHF-NYHA Ⅱ (NYHA Ⅱ group), and 92 with normal heart function (control group). The levels of Lp-PLA2, hs-TnT, NT-proBNP and left ventricular ejection fraction (LVEF) were detected in all groups. Results Compared with control group, the levels of Lp-PLA2 and hs-TnT increased significantly in all NYHA groups, and those were higher in NYHA Ⅳ group than those in NYHA Ⅲ group, and were higher in NYHA Ⅲ group than those in NYHA Ⅱ group (P<0.05). The level of Lp-PLA2 was positively correlated to level of hs-TnT (r=0.589, P<0.001), positively correlated to level of NT-proBNP (r=0.693, P<0.001), and negatively correlated to LVEF (r=-0.535, P<0.001). Conclusion Plasma Lp-PLA2 level is positively correlated with hs-TnT level and the severity of heart function. Lp-PLA2 can be taken as a new inflammatory indicator in CHF patients, and provides new evidences for judging the severity and pathogenesis of heart failure.

基金项目:

广东省韶关市卫生和计生科研项目(Y18060)

参考文献:

  • 2008

  • 1

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