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河南省郑州市缺血性心血管疾病的患病情况调查及危险因素分析

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摘要:

目的 调查河南省郑州市缺血性心血管疾病(ICVD)的患病情况,并分析ICVD发生的危险 因素。方法 采取整群随机抽样方法,于2016年抽取河南省郑州市5个社区/行政村≥35岁且居住时间>6个 月的居民作为研究对象,符合调查的研究对象共计10 618例。对所有研究对象进行问卷调查,并测量空腹 血糖(FPG)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固 醇(LDL-C)等指标水平,了解ICVD的患病情况,并分析其发生的因素。结果 最终共计纳入10 396例有 效研究对象,有效调查率为97.91%,其中ICVD患者723例,患病率为6.95%。ICVD组研究对象年龄≥60岁 (402例,55.60%)、其中心血管疾病家族史(164例,22.68%)、糖尿病病史(97例,13.42%)、吸烟史 (293例,40.53%)、体质指数(BMI)≥24 kg/m2(391例,54.08%)、高血压(295例,40.80%)、FPG水 平异常(84例,11.62%)、TC水平异常(124例,17.15%)、TG水平异常(170例,23.51%)、HDL-C水 平异常(137例,18.95%)以及LDL-C水平异常(102例,14.11%)均高于非ICVD组,差异均有统计学意义 (P<0.05)。Logistic回归分析结果显示有心血管疾病家族史(OR=3.093,95%CI:1.324~7.226)、BMI≥ 24 kg/m2(OR=2.349,95%CI:1.262~4.372)、高血压(OR=4.063,95%CI:1.685~9.797)以及TG水平异常 (OR=1.874,95%CI:1.126~3.119)是IVCD发生的危险因素。结论 河南省郑州市ICVD的患病率较高,其 中有心血管疾病家族史、BMI≥24 kg/m2、高血压及TG水平异常是ICVD发生的主要危险因素。

Abstract:

Objective To survey the prevalence of ischemic cardiovascular disease (ICVD) in Zhengzhou City of Henan Province, and analyze the risk factors of ICVD. Methods The residents were chosen (n=10618, aged ≥35, length of residence >6 months) as study subjects, by using cluster random sampling, from 5 communities/ administrative villages in 2016. A questionnaire was conducted in all study subjects. The levels of fasting plasma glucose (FPG), total cholesterol (TC), triglyceride (TG), high-density lipoprotein-cholesterol (HDL-C) and low-density lipoprotein-cholesterol (LDL-C) were detected. The prevalence of ICVD was investigated and the risk factors of ICVD were analyzed. Results There were totally 10396 effective subjects included, and effective investigation rate was 97.91%. Among them there were 723 patients with ICVD and the prevalence rate was 6.95%. In ICVD group, there were 402 cases aged≥60 (55.60%), 164 with family history of cardiovascular diseases (22.68%), 97 with family history of diabetes (13.42%), 293 with smoking history (40.53%), 391 with BMI≥24 kg/m2 (54.08%), 295 with hypertension (40.80%) and 84 with abnormal FPG level (11.62%). The percentages of cases with abnormal levels of TC (n=124, 17.15%), TG (n=170, 23.51%), HDL-C (n=137, 18.95%) and LDL-C (n=102, 14.11%) were higher in ICVD group than those in non-ICVD group (P<0.05). The results of Logistic regression analysis showed that the family history of cardiovascular diseases (OR=3.093, 95%CI: 1.324~7.226), BMI≥24 kg/m2 (OR=2.349, 95%CI: 1.262~4.372), hypertension (OR=4.063, 95%CI: 1.685~9.797) and abnormal TG level (OR=1.874, 95%CI: 1.126~3.119) were risk factors of IVCD. Conclusion The prevalence rate of ICVD is higher, Henan Province, Zhengzhou, and family history of cardiovascular diseases, BMI≥24 kg/m2, hypertension and abnormal TG level are main risk factors of ICVD.

基金项目:

“十二五”国家科技支撑计划项目“中国重要心血管病患病率调查及关键技术研究”河南地区的调查(2011BA111B01);国家卫生和计划生育委员会科研基“河南省重要心血管病及其相关危险因素流行病学调查”(201301002)

参考文献:

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